Dorsal Root Ganglion (DRG) Stimulation Portfolio

Portfolio Overview

  • A premier neurostimulation therapy for focal chronic pain conditions1
  • A premium platform offering the patient‐centric advantages of Invisible Therapy™
  • Delivers targeted stimulation for precise pain relief


With DRG stimulation you can achieve superior outcomes and deliver precise relief for patients suffering from focal chronic intractable pain.1

The Science Behind the DRG

The dorsal root ganglion (DRG) plays a critical role in the development and maintenance of chronic pain.2,3 It contains cell bodies of primary sensory neurons that undergo pathophysiologic changes underlying in chronic pain.4,5 The DRG’s unique pain processes and its anatomical considerations make it an ideal interventional target to treat various focal chronic intractable pain conditions.

The DRG has emerged as an exciting target for the management of focal intractable chronic pain.

Superior Pain Relief for Focal Chronic Intractable Pain

Conventional tonic SCS has been successfully used since 1967 to manage chronic, intractable pain in the trunk and/or limbs.5 But for pain locations outside of or more focal than the trunk and/or limbs—as seen in conditions such as CRPS, chronic intractable post-surgical knee pain and pain in the upper limbs—conventional tonic SCS has been less successful or has resulted in extraneous stimulation.1

Today there is a better solution: stimulating the dorsal root ganglion (DRG), which has been clinically proven to achieve pain relief in focal chronic intractable pain conditions.

Learn more about the Proclaim™ DRG Implantable Pulse Generator (IPG) Neurostimulator System, specifically designed to stimulate the DRG.

Infographic shows decrease in pain in patients who receive stimulation with DRG therapy
Analysis of DRG vs. control group in modified intention-to-treat population at 3 and 12 months

Proof That DRG Therapy Works 

DRG stimulation’s effectiveness has been proven in many international studies along with the U.S. ACCURATE study, the largest randomized neurostimulation clinical trial that compares conventional tonic SCS with DRG stimulation, to treat complex regional pain syndrome (CRPS).

Results were sustained at 12 months, with DRG stimulation providing overall treatment success in 74.2% of patients, versus 53.0% in traditional SCS patients.1 This study data suggests that DRG stimulation may offer a meaningful treatment aid for patients suffering from chronic pain conditions who are currently underserved by traditional SCS.

More Clinical Evidence

Proclaim™ DRG Implantable Pulse Generator (IPG) Neurostimulator System

St. Jude Medical offers the only systems specifically designed to stimulate the dorsal root ganglion (DRG)—the Proclaim™ DRG Implantable Pulse Generator (IPG) Neurostimulator System and Axium™ Neurostimulator System. Comprised of a specially engineered stimulation lead and lead delivery technology, our systems are designed to precisely deliver stimulation and optimize a patient’s unique pain therapy requirements.

See how our technology can empower you to treat patients with focal chronic intractable pain conditions with the Proclaim™ DRG Implantable Pulse Generator (IPG) Neurostimulator System.

Diagrammed drawing of the lumbar vertebrae (lower spinal cord)

Transforming the Treatment of Chronic Pain

At St. Jude Medical, our patient-focused approach to pain management is inspired by the care needs and challenges of patients with chronic pain. We offer the broadest range of therapies across the continuum of care to help physicians like you tailor your approach. Our investments in research, technology and partnerships can improve therapy outcomes and increase treatment options.

Partner with us to treat more patients with better results and transform the lives of more patients suffering from chronic pain.

Learn more about our approach to chronic pain


*When compared to traditional spinal cord stimulation based on outcomes from the ACCURATE IDE study.
**Based on new technologies available for DRG therapy.
***As studied in the ACCURATE clinical trial.
†Based on 12 month data studied in the ACCURATE IDE Study.
1. Deer, TR, Levy, RM, Kramer, J, et al. (2017). Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. Pain. 158(4): 669-681. ACCURATE IDE STUDY, St. Jude Medical. (n=152)
2. Abbott. Data on File. SJM-PDRG-1017-0016
3. Pope, J. E., Deer, T. R., & Kramer, J. (2013). A systematic review: Current and future directions of dorsal root ganglion therapeutics to treat chronic pain. Pain Medicine, 14(10), 1477-1496.
4. Sapunar, D., Kostic, S., Banozic, A., & Puljak, L. (2012). Dorsal root ganglion—a potential new therapeutic target for neuropathic pain. Journal of Pain Research, 5, 31-38. h
5. Devor, M. (1999). Unexplained peculiarities of the dorsal root ganglion. Pain, 82(Suppl. 1), S27-S35.
6. Chung, J. M., & Chung, K., (2002). Importance of hyperexcitability of DRG neurons in neuropathic pain. Pain Practice, 2(2), 87-97.

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