Heart Failure Management Portfolio

Single- and Dual-Chamber Quadra Allure MP™ RF CRT-P with MultiPoint™ pacing and lead

Portfolio Overview

  • Improving heart failure patient outcomes in a cost-effective manner1-6
  • Addressing CRT nonresponders with MultiPoint™ pacing
  • Enabling left ventricular pacing at the preferred site without compromising lead stability
  • Improving hemodynamic performance with unique quadripolar vectors7
  • Lowering rates of implant deactivation and replacement8
  • Improving the survival rate9 and quality of life9 for patients with NYHA class IIIB or IV heart failure


Elevate CRT Response With MultiPoint™ Pacing

Patients receiving MultiPoint™ pacing have demonstrated a 44% relative reduction in nonresponse at 12 months when compared to traditional Bi-V pacing with a quadripolar lead.13

Initial Results of the MOMENTUM 3 HeartMate 3™ LVAD Trial

Watch Dr. M. R. Mehra discuss first-cohort trial results, as well as the novel design, endpoints and other key features of the pivotal, ongoing MOMENTUM 3 U.S. IDE trial.

Discover details about the HeartMate 3™ left ventricular assist device, see more clinical evidence, download our initial results infographic or request that a St. Jude Medical representative contact you.


Unmatched Patient Success With CRT MultiPoint™ Pacing

Previous CRT technology has been plagued by a 30% nonresponder rate.14 MultiPoint™ pacing may be beneficial in increasing the number of patients who respond to CRT.15 MultiPoint pacing addresses the challenge of CRT nonresponders by:

  • Improving transventricular activation time16
  • Improving hemodynamics17
  • Delivering resynchronization throughout the left ventricle (LV)18
  • Allowing for pace timing to be adjusted to patient needs18

MultiPoint pacing has also demonstrated patient success in clinical studies. MultiPoint pacing has: 

  • Converted nonresponders to responders19
  • Improved left ventricular function for patients already responding20
  • Shown a 19% higher response rate than traditional CRT21
Infographic: MultiPoint™ Pacing has a 19% higher response rate than traditional CRT.(23)
Health care professional discussing results with a smiling patient

HF Clinical Evidence

The products in our HF management portfolio have substantial evidence showing they offer clinical improvements and operational efficiency.

Quadripolar technology

  • Lowers hospitalization rates22
  • Reduces mortality rates23

MultiPoint™ pacing

  • Improves CRT response rates24
  • Improves hemodynamic25,26 and acute hemodynamic response21,27

HeartMate 3™ LVAS

  • 98% survival at 30 days and 92% at 6 months9
  • 83% of patients improved to NYHA class I or II from NYHA class IIIB or IV9

See Clinical Evidence

Drawing of heart diagram with parts of the heart labeled with letters

Leading in the Advancement of Heart Failure Management

At St. Jude Medical, our vision is to transform the treatment of expensive epidemic diseases. To carry that out, we are dedicated to providing you with the broadest scope of innovative, cost-effective and outcome-driven solutions to manage heart failure and hypertension.

Learn more about our approach to heart failure and hypertension management.

REFERENCES


1. Tomassoni, G., Baker, J., Corbisiero, R., Love, C., Martin, D., Niazi, I., … & Harbert, N. (2011). Post operative performance of a novel left ventricular quadripolar electrode lead. Heart Rhythm, 8(5), S119. http://dx.doi.org/10.1016/j.hrthm.2011.03.024
2. Thibault, B., Dubuc, M., Guerra, P. G., Karst, E., Ryu, K., Paiement, P., … Farazi, T. (2011). Electrode selection to avoid phrenic stimulation with a quadripolar left heart lead. Heart Rhythm, 8(5), S68. http://dx.doi.org/10.1016/j.hrthm.2011.03.023
3. Dänschel, W., Spertzel, J., Gutleben, K. J., Kranig, W., Mortensen, P., Connelly, D., … Hallier, B. (2010). Initial clinical experience with a novel left ventricular quadripolar lead. Europace, 12(Suppl. 1), i127. http://dx.doi.org/10.1093/europace/euq127
4. Osca, J., Sanchez, J. M., Cano, O., Tejada, D., Munoz, B., Alonso, P., … Olague, J. (2011). Initial experience with a new quadripolar cable for left ventricular stimulation: Impact over phrenic nerve stimulation and pacing thresholds. Heart Rhythm, 8(5), S359. http://dx.doi.org/10.1016/j.hrthm.2011.03.031
5. Mehta, P. A., Shetty, A. K., Squirrel, M., Bostock, J., & Rinaldi, C. A. (2012). Elimination of phrenic nerve stimulation occurring during CRT: Follow-up in patients implanted with a novel quadripolar pacing lead. Journal of Interventional Cardiac Electrophysiology, 33(1), 43-49. http://dx.doi.org/ 10.1007/s10840-011-9598-5
6. Viani, S. M., Segreti, L., Di Cori, A., Zucchelli, G., Paperinin, L., Soldati, E., … Bongiorni, M. G. (2011).  A new quadripolar lead for left ventricular pacing: Short term reliability and future opportunities. Europace, 13(Suppl. 3). http://dx.doi.org/10.1093/europace/eur220
7. Forleo, G. B., Mantica, M., Di Biase, L., Panattoni, G., Della Rocca, D. G., Papavasileiou, L. P., … Romeo, F. (2012). Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: Early results of a prospective multicenter study. Heart Rhythm, 9(11), 1822-1828. http://www.ncbi.nlm.nih.gov/pubmed/22841876
8. Turakhia, M. P., Gold, M. R., Fischer, A., Sloman, L. S., Kumar, C., Dalal, N. … Cao, M., (2013). Decreased rate of left ventricular lead deactivation and replacement associated with use of quadripolar LV leads. Europace, 15(Suppl. 2), S47. http://dx.doi.org/10.1093/europace/eut169
9. Netuka, I. I., Beyersdorf, F., Garbade, J., Krabatsch, T., Marasco, S., Morshius, M., … & Zimpfer, D. (2015, September). HeartMate 3 fully magnetically levitated LVAD for the treatment of advanced heart failure: Results from the CE Mark Trial. Presented at the meeting of the Heart Failure Society of America, Washington, DC.
10. Cook, C., Cole, G., Asaria, P., Jabhour, R., & Francis, D. (2013). The annual global economic burden of heart failure. Journal of the American College of Cardiology, 171, 368-376. http://dx.doi.org/10.1016/j.ijcard.2013.12.028  
11. Neumann, T., Biermann, J., Erbel, R., Neumann, A., Wasem, J., Ertl, G., & Dietz, R. (2009). Heart failure: The commonest reason for hospital admission in Germany: Medical and economic perspectives. Deutsches Ärzteblatt International, 106(16), 269-275. http://dx.doi.org/10.3238/arztebl.2009.0269
12. Ponikowski, P., Anker, S., AlHabib, K., Cowie, M. R., Force, T. L., Hu, S., … Filippatos, G. (2014). Heart failure: Preventing disease and death worldwide. ESC Heart Failure, 1(1), 4-25. http://dx.doi.org/10.1002/ehf2.12005
13. Pappone, C., Calovic, Z., Vicedomini, G., Cuko, A., McSpadden, L. C., Ryu, K., … Santinelli, V. (2015). Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: Twelve-month follow-up study. Heart Rhythm, 12(6), 1250-1258. http://dx.doi.org/10.1016/j.hrthm.2015.02.008
14. Gurevitz, O., Nof, E., Carasso, S., Luria, D., Bar-Lev, D., Tanami, N., Eldar, M., & Glikson, M. (2006). Programmable multiple pacing configurations help to overcome high left ventricular pacing thresholds and avoid phrenic nerve stimulation. Pacing and Clinical Electrophysiology, 28(12), 1255-1259. http://dx.doi.org/10.1111/j.1540-8159.2005.00265.x
15. Rinaldi, C. A., Kranig, W., Leclercq, C., Kacet, S., Betts, T., Bordachar, P., … Nagvi, T. Z. (2013). Acute effects of multisite left ventricular pacing on mechanical dyssynchrony in patients receiving cardiac resynchronization therapy. Journal of Cardica Failure, 19(11), 731-738. http://dx.doi.org/10.1016/j.cardfail.2013.10.003
16. Theis, C., Bavikati, V. V., Langberg, J. J., & Lloyd, M. S. (2009). The relationship of bipolar left ventricular pacing stimulus intensity to cardiac depolarization and repolarization in humans with cardiac resynchronization devices. Journal of Cardiovascular Electrophysiology, 20(6), 645-649. http://dx.doi.org/10.1111/j.1540-8167.2008.01378.x
17. Champagne, J., Healey, J. S., Krahn, A. D., Philippon, F., Gurevitz, O., Swearingen, A., Glikson, M., & ELECTION Investigators. (2011). The effect of electronic repositioning on left ventricular pacing and phrenic nerve stimulation. Europace, 13(13), 409-415. http://dx.doi.org/10.1093/europace/euq499
18. Biffi, M., Exner, D. V., Crossley, G., Ramza, B., Coutu, B., Tomassoni, G., … Voss, F. (2011, May). Occurrence of phrenic nerve stimulation in CRT patients: The role of LV lead type and placement. Presented at the meeting of the Heart Rhythm Society, San Francisco, CA.
19. Thibault, B., Dubuc, M., Khairy, P., Guerra, P. G., Macle, L., Rivard, L., … Farazi, T. G. (2013). Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar LV lead. Europace, 15(7), 984-991. http://dx.doi.org/10.1093/europace/eus435
20. Pappone, C., Calovic, Z., Vicedomini, G., Cuko, A., McSpadden, L. C., Ryu, K., … Santinelli, V. (2014). MultiPoint left ventricular pacing improves acute hemodynamic response assessed with pressure-volume loops in cardiac resynchronization therapy patients. Heart Rhythm, 11(3), 394-401. http://dx.doi.org/10.1016/j.hrthm.2013.11.023
21. Corbisiero, R., Armbruster, R., & Muller, D. (2014, May). Reduced costs post CRT with quadripolar LV leads compared to bipolar LV leads. Presented at the meeting of the Heart Rhythm Society, San Francisco, CA.
22. Turakhia, M., Cao, M., Fischer, A., Arnold, E. M., Sloman, L. S., Dalal, N., & Gold, M. (2014, June). Reduced mortality with quadripolar compared to bipolar left ventricular leads in cardiac resynchronization therapy. Presented at the meeting of the World Congress in Cardiac Electrophysiology and Cardiac Techniques, Nice, France. Retrospective analysis; not prespecified.
23. Pappone, C., Calovic, Z., Cuko, A., McSpadden, L. C., Ryu, K., Romano, E., … Santinelli, V. (2013, September). Multipoint LV pacing in a single coronary sinus branch improves 3-month echocardiographic and clinical tesponse to CRT. Presented at the meeting of the Heart Failure Society of America, Orlando, Florida.
24. Rinaldi, C. A., Leclercq, C., Kranig, W., Kacet, S., Betts, T., Bordachar, P., … Nagvi, T. Z. (2014). Improvement in acute contractility and hemodynamics with multipoint pacing via a left ventricular quadripolar pacing lead. Journal of Interventional Cardiac Electrophysiology, 40(1), 75-80. http://dx.doi.org/10.1007/s10840-014-9891-1
25. Gutleben, K. J., Kranig, W., Barr, C., Morgenstern, M., Simon, M., & Lee, K., (2012, May). Multisite left ventricular pacing is safe and improves cardiac hemodynamic in heart failure patients—results from a 1-month follow-up study. Presented at the meeting of the Heart Rhythm Society, Boston, MA.
26. Pappone, C., Calovic, Z., Cuko, A., McSpadden, L. C., Ryu, K., Romano, E., … Santinelli, V. (2014, May). Multipoint left ventricular pacing in cardiac resynchronization therapy patients provides similar acute hemodynamic improvement regardless of QRS duration or lead location. Presented at the meeting of the Heart Rhythm Society, San Francisco, CA.
27. Graham, C. M., Gayle, J., & Magee, G. (2014, May). Comparison of healthcare utilization and hospital costs for quadripolar versus bipolar LV lead technologies. Presented at the meeting of the Heart Rhythm Society, San Francisco, CA.

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