Quadra Assura MP™ CRT-D

This device is commercially available for use in select international markets.

More Options to Make Non-Response a Non-Issue

The Quadra Assura MP™ CRT-D brings MultiPoint™ pacing, an exclusive St. Jude Medical™ technology, to cardiac resynchronization therapy defibrillators (CRT-Ds). The Quadra Assura MP CRT-D and Quartet™ quadripolar LV pacing lead feature four pacing electrodes and 10 pacing vectors, providing more options and greater control to minimize implant complications such as diaphragmatic stimulation and high pacing threshold.

Quadra Assura MP CRT-D is an MRI Ready device when used in combination with MR Conditional leads. This device has been tested for safe performance of an MRI scan using a 1,5 T (Tesla) field-strength MRI scanner.^a,b

One lead. Two impulses. More options to manage CRT response.

With MultiPoint™ pacing, St. Jude Medical has built on the quadripolar standard of care to offer more pacing options for your patients. MultiPoint pacing delivers two LV pulses from a single Quartet™ LV lead for greater tissue capture.^1-3

MultiPoint™ pacing results

U.S. IDE study: Evidence for improved outcomes⁴

The recent IDE study⁴ post-hoc subanalysis (n = 199) showed that wider cathode spacing and near-simultaneous intraventricular timing delays provide best MPP™ technology response at 87 percent and “super-response” at 54 percent (52 patients).⁴

See details of the U.S. IDE study and other clinical support for MultiPoint pacing.

MultiPoint™ pacing has also demonstrated:

• 90% response rate with MultiPoint pacing at 12 months measured by ESV decrease > 15%⁵
• 95% response rate with MultiPoint pacing at 12 months measured by ≥ 1 decrease in NYHA class⁵
• 90% response rate with MultiPoint pacing at 12 months measured by Packer’s score⁵
• 19% absolute improvement in patients for CRT response at 12 months when compared to traditional biventricular (BiV) pacing with a quadripolar lead⁶
• 44% relative reduction in nonresponders at 12 months when compared to traditional BiV pacing with a quadripolar lead⁶

Electrical, mechanical and hemodynamic benefits

• MultiPoint pacing was able to recruit a greater portion of the LV than traditional BiV pacing, resulting in reduced activation times and QRS duration.⁷
• MultiPoint pacing reduced mechanical dyssynchrony by more than 20% as measured with tissue Doppler imaging in 63% of 41 patients tested.²
• MultiPoint pacing improved acute LV contractility assessed with pressure wire in 84% of patients compared to BiV pacing.⁸
• Multiple studies have shown improvement in QRS duration, EF and ESV at six months.^9-11

Enhanced programming options with Quadra Assura MP™ CRT-D

• SyncAV™ CRT technology automatically adjusts pacing based on real-time changes in a patient’s cardiac condition.
• Auto VectSelect Quartet™ Test elevates response easily, offering an efficient workflow for complete results and programming at the touch of a button.
• Antitachycardia pacing (ATP) while charging and prior to charging in the VF zone further extends the programming options for terminating tachyarrhythmias without a high-voltage shock.
• SenseAbility™ feature provides flexibility to fine-tune programming around T-wave oversensing without decreasing sensitivity.

Additional monitoring and safety features of Quadra Assura MP™ CRT-D

• ShockGuard™ technology with DecisionTx™ programming
• SecureSense™ RV lead noise discrimination
• Far Field MD™ morphology discrimination
• DeFT Response™ technology
• CorVue™ congestion monitoring feature
• QuickOpt™ timing cycle optimization

Building comprehensive heart failure management

The Quadra Assura MP™ CRT-D is part of our heart failure management portfolio. Our vision is to transform the treatment of heart failure by designing technology that delivers excellent clinical outcomes and improves workflow and efficiency. Read more about the portfolio and our approach to heart failure management.